Using cavitation rheology to understand dipeptide-based low molecular weight gels

Low-Molecular-Weight Gels: The State of the Art

The Bigger Picture Gels are ubiquitous soft solids that are widely used in everyday life. Most gels are based on polymeric materials, as either entangled biopolymers or covalently crosslinked networks. Low-molecularweight gels, or supramolecular gels, are another fascinating and useful class of gel. Here, the assembly of small molecules into a network immobilizes the solvent. These materials ar...

Antidepressant Effect of Dimeric Dipeptide GSB-106, an Original Low-Molecular-Weight Mimetic of BDNF

A large amount of clinical and experimental data suggest the involvement of neurotrophins, in particular the brain-derived neurotrophic factor (BDNF), in depression pathogenesis. However, the therapeutic use of BDNF is limited because of its instability in biological fluids, poor blood-brain barrier (BBB) permeability, and the presence of side effects. A low-molecular-weight mimetic GSB-106, wh...

Rheology of biopolymer solutions and gels.

Rheological techniques and methods have been employed for many decades in the characterization of polymers. Originally developed and used on synthetic polymers, rheology has then found much interest in the field of natural (bio) polymers. This review concentrates on introducing the fundamentals of rheology and on discussing the rheological aspects and properties of the two major classes of biop...

Low Molecular Weight Heparin Overdose: A 10 Year Case Series

  Background: Low molecular weight heparin (LMWH) is used for the treatment and prevention of coagulative disorders. Few patients receiving therapeutic doses of LMWH develop major hemorrhage. Currently there are few reports in the literature on acute overdose on adults.  In this study, clinical profile, treatment and outcome of 21 patients who acutely overdosed enoxaparin are described. Method...

Low molecular weight heparin.